Depression is a complex disease. Symptoms can range from irritability, feelings of worthlessness and loss of energy, just to name a few. (Some individuals even report physical changes such as gastrointestinal problems and chronic joint pain.)
The signs and symptoms of depression vary and the therapies designed to manage the condition are diverse as well. And, patients react to those treatments in different ways. Given that, how can clinicians pinpoint which therapy (or combination of therapies) for depression will work the best?
Answering this question underlies the basis of the research directed by Conor Liston, a psychiatrist at Weill Cornell Medical College. Liston and his team are currently working to classify the various subtypes of depression using MRI scans of the brain and then identify the most effective treatments for each subtype.
The scientists first scanned the brains of 1,118 research participants. Among those, 458 had already received a clinical diagnosis of depression. Specifically, they wanted to better understand the level of activity among the medial prefrontal cortex and other areas of the brain. After reviewing the MRIs for various patterns of brain activity, Liston and team were able to identify four distinct depression subtypes.
And their results were remarkable. Among those with depression, they found that each subtype responded very differently to various therapies and medications. Based on the research findings, the scientists could predict how to best treat the patient for depression just by reviewing an image of their brain activity. In general, patients that exhibited a lot of activity in their medial prefrontal cortex responded more quickly to cognitive behavioral therapy in contrast to individuals with lower levels of activity in that region of the brain.
“The type of brain that responds to psychotherapy is where there’s a strong pattern of connectivity between the frontal areas of the brain, which are involved more in thinking, talking, and problem-solving, etc., with other portions of the brain. Whereas people who have low connectivity — the opposite pattern — respond to the medication,” says psychologist W. Edward Craighead, one of the authors of this study.
Individuals with behavioral health issues, such as depression, often struggle with addiction. That’s why we specialize in offering a variety of mental health services for Christians. To help address a complex dual-diagnosis, we can help with medication management, group and individual therapy and faith-based support. If you are dealing with behavioral health and addiction issues, please call (877) 310-9545 to explore your addiction treatment options at Christian Rehab Network.
Due to the dramatic and widespread increase in opioid addiction, the scientific community has responded by investing in new therapies to alleviate the symptoms of withdrawal and treatments designed to address addiction issues.
In addition to that good work, some researchers are also asking that we spend time investigating the underpinnings of addiction. Specifically, they suggest that we should learn more about the basic biology of pain and how precision medicine can help us predict how patients will respond to certain prescription painkillers.
In an article published recently in the journal Science, researchers from the Perelman School of Medicine at the University of Pennsylvania recommend that we adopt a paradigm shift. Instead of solely focusing on treatment methodologies, we should also go back to the basics and investigate the nature of pain and how people differ in their response to various pain medications. Armed with this information, clinicians can administer prescription painkillers more precisely and reduce the risk of triggering an addiction.
"Pain is a syndrome that is poorly understood and research on pain is poorly resourced relative to its prevalence and cost, especially in terms of shattered lives and lost productivity," writes Tilo Grosser, MD, one of the lead authors and an associate professor of Pharmacology at the University of Pennsylvania.
To tackle the opioid epidemic, the researchers suggest that we employ a broader strategy. Specifically, addiction research should help us better understand the physiology of pain. They recommend that additional studies should investigate how and why individuals respond differently to pain. And, the researchers also suggest that more can be learned by exploring the difference between inflammatory and neuropathic pain, the heritability of pain awareness and the spectrum of acute and chronic pain.
By investigating the biology and mechanics of pain, we can help to prevent addiction before it occurs. At Christian Rehab Network, it’s encouraging that more scientists are recognizing the need to develop safer and less addictive treatment therapies for pain. Let’s keep this positive momentum going.
If you have an addiction to drugs or alcohol, our compassionate staff is here to help. At Christian Rehab Network, we can help verify your insurance coverage and benefits and ensure you get connected with the right center that specializes in addressing your specific needs. And, we can take care of all the paperwork so you don’t have to during a time of crisis. Let us help you find the best drug or alcohol rehab center to meet your individual needs. Contact us today at (877) 310-9545.